| Titolo | Nuclear SOD1 links ATM-CHK2 signaling to ADH5/GSNOR transcription in SHSY-5Y SOD1G93A cellular models of ALS |
|---|---|
| Tipo di pubblicazione | Articolo su Rivista peer-reviewed |
| Anno di Pubblicazione | 2026 |
| Autori | Pecorari, Chiara, Montagna Costanza, Cozzolino Mauro, D'Ambrosi Nadia, Benassi Barbara, Cirotti Claudia, and Filomeni Giuseppe |
| Rivista | Nitric Oxide - Biology and Chemistry |
| Volume | 164 |
| Paginazione | 69 - 74 |
| Type of Article | Article |
| ISSN | 10898603 |
| Abstract | The activity of S-nitrosoglutathione reductase (ADH5/GSNOR) has been proposed being essential to limit oxidative stress and preserve mitochondrial quality control. Here we identify a redox-dependent ATM-CHK2-SOD1 signaling axis that drives ADH5/GSNOR transcription in SH-SY5Y cells expressing the ALS-associated SOD1G93A mutant. ATM-CHK2 activation promotes the interaction of SOD1 with CHK2, leading to SOD1 nuclear translocation and binding to the ADH5 promoter. Pharmacological inhibition of ATM or CHK2 abolishes these effects. ADH5/GSNOR overexpression protects cells from SOD1G93A-induced toxicity suggesting that the modulation of GSNOR activity may represent a potential strategy to restore redox homeostasis in ALS. © 2026 Elsevier Inc. |
| Note | Cited by: 0 |
| URL | https://www.scopus.com/pages/publications/105047064890?origin=resultslist |
| DOI | 10.1016/j.niox.2026.08.001 |
| Citation Key | Pecorari202669 |
